Levomitsetin of фарм (Chloramfenicolum) 2941400000
Chloramphenicol (chloramphenicol) is a broad-spectrum antibiotic. Colorless crystals of extremely bitter taste. Chloramphenicol is the first synthetic antibiotic. It is used to treat typhoid fever, dysentery and other diseases. Toxic. Chloramphenicol has a bacteriostatic effect, which is associated with a violation of protein synthesis by ribosomes.
In high concentrations, has a bactericidal effect against pneumococcus, meningococcus and H. influenzae ... Chloramphenicol has a broad spectrum of antimicrobial activity, But in the process of many years of use, a number of bacteria have acquired resistance. Among gram-positive cocci, pneumococcus is most sensitive to the drug, but many penicillin-resistant strains are resistant. Enterococci are generally insensitive. Among staphylococci, more than 30% of strains are resistant. Of the gram-negative cocci, meningococci are the most sensitive.
Chloramphenicol acts on many gram-positive and gram-negative bacilli: H. influenzae (including ampicillin-resistant strains), E. coli, salmonella, shigella, causative agents of diphtheria, whooping cough, anthrax, brucellosis, plague. Among enterobacteria, resistance is often noted. In Russia, 50-90% of Shigella and 10% of Salmonella are resistant to chloramphenicol. Spirochetes (leptospira, T. pallidum), rickettsiae, actinomycetes are sensitive to chloramphenicol.
The drug has high activity against spore-forming and non-spore-forming anaerobes, including B.fragilis .
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